Alternative Repair Models Capable of Generating Shouldered Dose-response Curves
نویسندگان
چکیده
منابع مشابه
A new model of shouldered survival curves.
Recently, the linear-quadratic equation has been used to construct the dose-response relationships of ionizing radiation. The radiobiological theory on which this relationship is based indicates that at low doses, the risk of a biological lesion being formed should depend linearly on dose if a single event is required or quadratically on dose if two events are required. The same approach has al...
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We develop tools from computational algebraic geometry for the study of steady state features of autonomous polynomial dynamical systems via elimination of variables. In particular, we obtain nontrivial bounds for the steady state concentration of a given species in biochemical reaction networks with mass-action kinetics. This species is understood as the output of the network and we thus bound...
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To the Editor:—The critique by Eger et al. on the article by Eckenhoff and Johansson concerns combining the dose–response curves of several ion channels to make them steeper. The slopes of the in vivo studies are steep, whereas those of the in vitro studies are gradual. Both groups anticipate that when several binding sites among ion channels are combined, the dose–response curves may become st...
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A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...
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Our ability to recreate complex biochemical mechanisms in designed, artificial systems provides a stringent test of our understanding of these mechanisms and opens the door to their exploitation in artificial biotechnologies. Motivated by this philosophy, here we have recapitulated in vitro the "target sequestration" mechanism used by nature to improve the sensitivity (the steepness of the inpu...
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ژورنال
عنوان ژورنال: International Journal of Radiation Biology
سال: 1991
ISSN: 0955-3002,1362-3095
DOI: 10.1080/09553009114550881